Low dose testosterone could be a game changer for testosterone therapy, a new study finds.
The study was published online in the American Journal of Physiology-Endocrinology and Metabolism.
Low doses of testosterone are often used in male-to-female transsexual therapy.
“This is the first randomized controlled trial of testosterone therapy that has used the low dose approach, which has been used for several decades to treat male-female transgenderism,” said Dr. James M. Bresnahan, M.D., Ph.
D. and a member of the Department of Pharmacology and Toxicology at Columbia University Medical Center in New York City.
“The results showed that testosterone therapy reduced the frequency of men having erections and decreased the incidence of prostate cancer in both men and women with the condition.
It also reduced the incidence and severity of osteoporosis, and the side effects of treatment.”
In addition to reducing the frequency and severity, testosterone therapy also reduced prostate cancer risk by reducing inflammation and lowering inflammation-related markers, which are often associated with prostate cancer.
In the study, researchers randomly assigned 50 male- to female-transgender patients to receive a single dose of either 20 mg testosterone gel or 20 mg saline in the morning or afternoon.
The participants were followed for five years.
Participants who received testosterone gel had lower erectile dysfunction scores, and they were less likely to develop prostate cancer and osteoporsis.
They also had significantly lower prostate cancer rates.
In addition, they were more likely to be free of osteosarcoma, the leading cause of death in men, compared to those who received placebo.
“When you have the highest levels of testosterone, you’re more likely, if you’re lucky, to have lower rates of osteoarthritis, or osteoporation,” said study researcher Dr. Robert E. Todenhofer, M, PhD, a researcher in the Department Of Pharmacology & Toxicology.
“If you’re looking for a treatment for a chronic condition like osteoarthropathy, this could be one way to help.”
“If testosterone therapy were used in a randomized controlled study, it would be the most important treatment in the world for this condition,” said Bresner.
“And I think that’s a big deal.”
A small, one-day trial in the Netherlands showed that low dose hormone therapy reduced prostate cancers in women.
However, the trial had a high number of adverse events, including the most serious of which, heart failure.
“There are a lot of issues that need to be addressed in terms of the safety of testosterone treatment,” Bresnan said.
It may not be effective for some women, and testosterone therapy needs to continue to be tested for efficacy and safety.” “
As we know, testosterone is a hormone that is extremely effective for treating some men with osteo-arthritis.
It may not be effective for some women, and testosterone therapy needs to continue to be tested for efficacy and safety.”
Low doses have been used in men with hypogonadism and prostate cancer for decades.
However to date, studies have not shown a benefit in terms for men with erectile dysfunctions and prostate cancers.
“Treating male-pattern baldness and acne is a new thing for testosterone,” said M.K. Bambach, MSc, MPhil, a member from the Department for Ophthalmology & Visual Sciences at the University of Toronto Medical School in Toronto, Canada.
“I think it’s important to take testosterone and try to change the pattern.
I think testosterone therapy is a really interesting treatment option for people who have these problems.
The only problem is, it’s not available to everyone.”
“We need to find out what works, and what doesn’t work,” Bambacher said.
Bregman, who is currently a postdoctoral fellow at the Johns Hopkins University School of Medicine in Baltimore, Maryland, also believes that testosterone treatment is an option that should be explored in men.
“We don’t really know what works in this condition, so it’s interesting to try different combinations,” he said.