T-RNT-1: The gene of testosterone structure is ‘a bit of a mystery’

Researchers have created a gene that allows them to produce more testosterone in mice, suggesting that it might be a gene for higher levels of testosterone in men. 

In a study published in Nature Genetics, the researchers showed that mice with a variant of the T-protein in their cells produced testosterone at a higher rate than mice without the gene. 

But the research team noted that this difference is “still small” and they don’t yet know how the T gene works. 

“It’s a bit of an interesting gene to know because we don’t know if this gene can affect sex differences in men or in women,” lead author Michael C. Wiebe, a geneticist at the University of California, Santa Barbara, told Al Jazeera. 

Wiebe and his colleagues are also looking into how the gene interacts with other genes and how that might affect testosterone levels.

The T-T-R-1 gene encodes a T-type protein that helps regulate the function of a hormone called testosterone. 

When a gene called TTR is mutated, the T protein becomes inactive, and testosterone levels plummet. 

As testosterone levels fall, the body produces more and more T cells to help support testosterone production.

The researchers’ work was based on the TTP gene, which encodes two proteins that bind to the T proteins and cause the T genes to be inactive. 

Researchers also discovered that T-tru-1, a gene which encases a T1 receptor, and T-truncated-1 encodes another receptor that blocks T-trait. 

The scientists used genetic engineering to create a transgenic mouse that had two mutated TTP genes. 

Their transgenic mice were then given testosterone injections, and then tested for their testosterone levels and their levels of the other T proteins. 

To see whether the TTR gene affected testosterone levels, they also tested the transgenic male mice. 

While they were able to show that TTP was increased in transgenic males, their testosterone level didn’t change. 

This is the first time that researchers have shown that a gene is responsible for testosterone production, Wieb said. 

Previous research has shown that TTR can increase testosterone levels in humans, but the exact mechanism for this is not known.

Wieb, who is a member of the Stanford Department of Genome Science and Genetics, and his team are currently investigating other factors that might increase testosterone production in the body. 

 Wiesbe said the team will now try to find out more about how TTR regulates testosterone levels more broadly. 

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